Table 1.

Phosphorylated substrates of NAK family. Substrates and their phosphorylation sites reported for Numb-associated kinases are listed. Furthermore, the related physiological functions are also summarized in this table

Protein	Alias	Substrates	P-sites/motifs of the substrates	Physiological function	Reference
AAK1		AP-1	T154	Regulation of clathrin-dependent endocytosis; Endosomal pathway	[10] [8] [27]
		AP-2	T156
		Numb	T102	Dendritic morphogenesis of developing mammalian neurons
		Eps15	-	Positive regulation of Notch signaling pathway
GAK	Auxilin	AP-2	T156	Process clathrin coat disassembly; Receptor-mediated endocytosis	[55] [56] [57] [58]
		AP-1	-
		Atp1a3	T705	Na+/K+-ATPase
		CHC	T606	Mitosis; Microtubule generation and outgrowth
		Protein phosphatase 2 A	T104
BMP2K	BIKE	AP-2	T156	Clathrin-dependent endocytosis	[14] [59]
		CLINT1	T294	Cell signaling
MPSK1	Krct, EDPK, STK16, TSF-1, PKL12	MBP	-	Secretory vesicle trafficking	[60] [61] [62] [63]
		Histone H1	-
		PHAS-1	-	-
		DRG1	-	Cellular growth
PRK1	Prk1p	Pan1	The LxxQxTG motifs	Actin cortical patch assembly; Endocytosis; TORC2-Dependent Signaling Network in yeast	[64] [65] [66] [18] [67]
		Sla1	The LxxQxTG motifs
		Ent1/2	T394, T416
		Scd5	The LxxTxTG motifs
		Bni1	The LxxQxTG motifs	Exocytosis
ARK1	Ark1p	Pan1	The LxxQxTG motifs	Actin cortical patch assembly; Clathrin-dependent endocytosis; TORC2-Dependent Signaling Network in yeast	[64] [65] [18]
		Sla1	The LxxQxTG motifs
AKL1	Akl1p	Sal1	The LxxQxTG motifs	Clathrin-dependent endocytosis; TORC2-Dependent Signaling Network in yeast	[68] [22] [23]
		Pan1	-
		Ent1	-
		Fpk1	-
Nak		AP-2	T156	Endocytosis in Drosophila	[69] [70]
		Numb	-	Asymmetric cell division
Auxilin		AP-2	-	Clathrin coat disassembly; Receptor-mediated endocytosis; Compound eye morphogenesis; Notch signaling pathway	[55]
		AP-1	-