Table 2.
Multivariate Cox Regression Analysis for the Clinical Model, Radiomic Principal Components (RPC) Model and Dosiomic Principal Components (DPC) Model respectively.
| HR (95% CI) | z | P value | |
|---|---|---|---|
| Clinical Model (AIC, 158.61; C-index, 0.663; 95% CI, 0.600–0.725) | |||
| Gender | 0.68 (0.20-2.35) | -0.61 | 0.54 |
| Age | 0.92 (0.85-1.00) | -1.99 | 0.05 |
| Stage | 1.09 (0.38-3.16) | 0.16 | 0.87 |
| Peripheral invasion | 1.25 (0.44-3.51) | 0.42 | 0.67 |
| RPC Model (AIC, 150.73; C-index, 0.762; 95% CI, 0.708–0.815) | |||
| RPC0 | 1.10 (1.04-1.17) | 3.26 | <0.01 |
| RPC1 | 1.08 (0.98-1.21) | 1.49 | 0.14 |
| RPC2 | 0.94 (0.83-1.07) | -0.96 | 0.34 |
| RPC3 | 0.94 (0.79-1.12) | -0.68 | 0.49 |
| RPC4 | 0.78 (0.60-1.03) | -1.78 | 0.08 |
| DPC Model (AIC, 146.33; C-index, 0.783; 95% CI, 0.734–0.832) | |||
| DPC0 | 1.08 (1.03-1.14) | 3.33 | <0.01 |
| DPC1 | 1.04 (0.92-1.19) | 0.64 | 0.52 |
| DPC2 | 0.94 (0.82-1.06) | -1.03 | 0.30 |
| DPC3 | 0.76 (0.60-0.97) | -2.16 | 0.03 |
| DPC4 | 1.07 (0.90-1.28) | 0.80 | 0.42 |
HR, hazard ratio; z, Wald statistic value, the ratio of each regression coefficient to its standard error; CI, confidence interval; RPC, Radiomic Principal Component; DPC, Dosiomic Principal Component; RPCn, DPCn, The nth RPC and DPC obtained by principal component analysis and ranked by weight respectively.