TABLE 1.
Summary of T-Cell Batches Used in This Study
| %Vα24+ of CD3+ lymphocytes (%TCR+) | %CD8α+ of CD4+ Vα24+ | |||||||
|---|---|---|---|---|---|---|---|---|
| Batch | Used in figures | HLA-A*02:01 status | ntd | ADP-A2M4 | ADP-A2M4CD8 | ntd | ADP-A2M4 | ADP-A2M4CD8 |
| Large scale | ||||||||
| L213 | 1, 2, 4, S1, S7 | + | 0.94 | 64.3 | 59 | 0 | 0.9 | 97.8 |
| L214 | 1, 4, S1, S4, S7 | − | 0.7 | 60.4 | 55 | 0 | 0 | 98.7 |
| L215 | 1, 4, 5, S1, S4, S7 | − | 0.8 | 44.4 | 44.1 | 0 | 2.89 | 98 |
| L216 | 1, 3–5, S1, S4, S6, S7 | + | 0.62 | 54.7 | 56.9 | 0 | 0 | 98.3 |
| L217 | 1–5, S1, S4, S6, S7 | + | 0.94 | 57.1 | 61.2 | 0 | 0 | 99 |
| Small scale | ||||||||
| SS1 | 3, S6 | + | 0.76 | 54.8 | 58.3 | 0 | 0 | 98.6 |
| SS2 | 3, S6 | + | 1.04 | 45.3 | 44.9 | 0 | 0.24 | 98.1 |
| SS3 | 2 | + | 0.79 | 52.6 | 50.1 | 0.64 | 0.012 | 98.6 |
| SS4 | 2 | + | 0.95 | 42.9 | 46.9 | 0 | 0.11 | 98.3 |
Small-scale and large-scale T-cell batches used in the study. Each batch was manufactured from a different healthy donor. HLA-A*02:01 status, TCR transduction efficiency (%Vα24), and expression of CD8α within CD4+ Vα24+ population of T cells are also described for each product.
ntd, nontransduced; S, Supplemental; TCR, T-cell receptor.