TABLE 5.
IC50 values of selected copper complexes 1–8, free ligands (L) and cisplatin (µM ± SD) on A-375 and A-549 cell lines.
| IC50 (µM ± SD) | |||||||
|---|---|---|---|---|---|---|---|
| A-375 | A-549 | ||||||
| 1 | 2.7 ± 0.03 | L1 | 12.3 ± 0.5 | 1 | 4.2 ± 0.2 | L1 | >50 |
| 2 | 6.5 ± 0.8 | L2 | >50 | 2 | 9.3 ± 0.4 | L2 | >50 |
| 3 | 5.1 ± 0.3 | L3 | 23.9 ± 1.5 | 3 | 8.9 ± 0.2 | L3 | >50 |
| 4 | 2.0 ± 1.3 | L4 | >50 | 4 | 3.9 ± 0.6 | L4 | >50 |
| 5 | 3.4 ± 0.1 | L5 | 30.9 ± 0.3 | 5 | 5.1 ± 0.01 | L5 | >50 |
| 6 | 13.6 ± 0.9 | L6 | 21.2 ± 0.2 | 6 | 16.0 ± 0.3 | L6 | 46.9 ± 0.8 |
| 7 | 5.1 ± 0.4 | L7 | 12.4 ± 0.2 | 7 | 9.3 ± 0.2 | L7 | 23.6 ± 0.2 |
| 8 | 2.8 ± 0.4 | L8 | 9.1 ± 1.9 | 8 | 5.1 ± 0.2 | L8 | 45.1 ± 2.7 |
| cisplatin | 11.2 ± 0.3 | cisplatin | 16.5 ± 3.4 | ||||