Table 5.

Details of some common miRNAs used in target therapy for the treatment of meningioma

Drug name	Drug Composition/molecular formula administration			Mechanism of action	Type of study		References
MicroRNA
miR-29c-3p		miRNA	A study revealed that miR-29c-3p promoted the malignant development of HCC by regulating the methylation of LATS1 caused by DNMT3B and inhibiting the anticancer function of the Hippo signaling pathway			Simultaneous analysis of miRNA–mRNA in human meningiomas by integrating transcriptome, investigating the relationship between PTX3 and miR-29c		[120, 121],
miR-219-5p		miRNA	Overexpression of miR-219-5p can inhibit gastric cancer cell malignancy by targeting the liver receptor homolog-1/Wnt/β-catenin signaling pathways			This microRNA expression signature predicts meningioma recurrence		[120, 122]
miR-190A		miRNA	A recent study showed that miR-190a is involved in estrogen receptor (ERα) signaling, causing inhibition of breast tumor metastasis			While miR-190a is downregulated in aggressive neuroblastoma (NBL), its overexpression leads to the inhibition of tumor growth and prolonged dormancy periods in fast-growing tumors8		[120]
miR-145		miRNA	miR-145 may serve as a tumor suppressor which can downregulate E-cad expression by targeting MUC1, leading to the inhibition of tumor invasion and metastasis			MiRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates the motility and proliferation of meningioma cells		[120, 122]
miR-335		miRNA	miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas			miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas		[120, 123]