Figure 1. Overview of available Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genome sequences from different animal species.

(A) Barplot of the number of genome sequences available in GISAID (on February 28, 2022) sampled from each animal species. Only species with 50 or more sequences were included in the current study: cat, dog, mink, and deer. (B) Heatmap of animal-associated mutations identified in previous publications. Darker colors indicate mutations found in a greater number of studies. Each row corresponds to one of the species included in this study, and columns correspond to mutations along the SARS-CoV-2 reference genome. Mutations identified as family-wise significant (p<0.05) in our genome-wide association studies are indicated with an orange asterisk. A detailed list of publications reporting these mutations is in Supplementary file 8. Only single nucleotide variants, not insertions or deletions, are included. The heatmap illustrates the results of several key prior studies but does not represent a comprehensive meta-analysis.