Table 1.
Change in Lipid Profile in Transgender Individuals Over Time After Initiating Hormone Treatment, From the Meta-Analysis15
| Estimate | 95% CI | I2 | No. studies | |
|---|---|---|---|---|
| Transgender women with GAHT | ||||
| 3–6 months | ||||
| Triglyceride (mg/dL) | 3.8 | −11.6, 19.3 | 63.5 | 6 |
| LDL-C (mg/dL) | −3.1 | −11.6, 5.4 | 0 | 3 |
| HDL-C (mg/dL) | 1.2 | −5.7, 8.1 | 70.0 | 5 |
| Total cholesterol (mg/dL) | −1.1 | −9.4, 7.2 | 0 | 4 |
| 12 months | ||||
| Triglyceride (mg/dL) | 13.6 | −6.4, 33.6 | 89.5 | 10 |
| LDL-C (mg/dL) | −5.7 | −19.5, 8.1 | 85.1 | 7 |
| HDL-C (mg/dL) | 0.3 | −4.3, 5.0 | 77.4 | 8 |
| Total cholesterol (mg/dL) | −7.9 | −19.9, 4.1 | 82.5 | 10 |
| ≥24 months | ||||
| Triglyceride (mg/dL) | 31.9 | 3.9, 59.9 | 94.4 | 6 |
| LDL-C (mg/dL) | 6.6 | −9.7, 22.9 | 83.9 | 5 |
| HDL-C (mg/dL) | 0.4 | −7.7, 8.5 | 93.5 | 5 |
| Total cholesterol (mg/dL) | 9.5 | −5.8, 24.9 | 87.4 | 6 |
| Transgender men with androgen | ||||
| 3–6 months | ||||
| Triglyceride (mg/dL) | 9 | 2.5, 15.5 | 7.7 | 4 |
| LDL-C (mg/dL) | 7.1 | −3.2, 17.3 | 0 | 3 |
| HDL-C (mg/dL) | −6.5 | −11.9, −1.0 | 0 | 3 |
| Total cholesterol (mg/dL) | 10.6 | −4.2, 25.4 | 73.6 | 4 |
| 12 months | ||||
| Triglyceride (mg/dL) | 14.7 | −2.7, 32.1 | 75.4 | 9 |
| LDL-C (mg/dL) | 11.3 | 5.5, 17.1 | 0 | 8 |
| HDL-C (mg/dL) | −8.1 | −10.6, −5.7 | 0 | 8 |
| Total cholesterol (mg/dL) | 12.0 | −3.7, 27.8 | 88.0 | 9 |
| ≥24 months | ||||
| Triglyceride (mg/dL) | 21.4 | 0.1, 42.6 | 80.0 | 3 |
| LDL-C (mg/dL) | 17.8 | 3.5, 32.1 | 84.1 | 3 |
| HDL-C (mg/dL) | −8.5 | −13.0, −3.9 | 70.7 | 3 |
| Total cholesterol (mg/dL) | 14.6 | −5.1, 34.3 | 90.2 | 3 |
Reproduce with permission from Maraka S, et al.15 GAHT, gender-affirming hormone therapy; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.