Skip to main content
. Author manuscript; available in PMC: 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Feb 2;83(5):803–818.e8. doi: 10.1016/j.molcel.2023.01.015

Figure 1. Overview of kinobead competition and correlation analysis (kiCCA), a chemoproteomic approach for rapid, sensitive, and highly multiplexed kinase protein-protein interaction (PPI) profiling.

Figure 1.

(A) Kinome profiling with kinobead/LC-MS and kinase inhibitor (KI) soluble competition identifies co-precipitating kinase complexes.

(B) Workflow of our kiCCA analysis using 21 kinase interactome probes (KIPs) to identify multiple kinase complexes in the same experiment.