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. 2023 Apr 4;14:1638. doi: 10.1038/s41467-023-37269-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Overview of untargeted plasma proteomics on sera from pediatric patients with COVID-19 (COVID + ), MIS-C, or healthy controls. B Relative abundance of detected peptides per sample (Healthy n = 7, COVID + n = 7, MIS-C n = 5, SD). C PCA plot of proteomics data for pediatric group. D Venn diagram showing the relative distribution of differentially abundant proteins (DAPs). E Comparison of DAPs to the human genome atlas highlights perturbations in liver and lung; gold reflects MIS-C compared to healthy controls while blue reflects COVID + compared to healthy controls. F KEGG pathway analysis highlights alterations in pathways common between MIS-C and COVID + cohorts. G KEGG pathway analysis of those significant in either MIS-C (gold) or COVID + (blue) highlights perturbations unique to each group, neither of which achieve significance for the fluid shear stress or ECM-receptor interaction pathways identified in the adult cohort. H Heat map of identified DAPs altered upon SARS-CoV-2 infection in children. I The abundance of all 3 chains of the hepatic acute phase protein fibrinogen is not significantly increased in pediatric COVID + or MIS-C patients (Healthy n = 7, COVID + n = 7, MIS-C n = 5, two-way ANOVA, SD). Source data are provided as a Source Data file.