Table 1.
The role of methyltransferases and their regulated ncRNAs in various cancers.
| Writer | Role in cancer | Type | Target ncRNAs | Mechanism |
|---|---|---|---|---|
| METTL3 | Oncogene | CC | LncFOXD2-AS150 | Stability |
| circ000006963 | Stability | |||
| LncZFAS157 | Adsorb microRNAs | |||
| HCC | LncAROD49 | Stability | ||
| LNC127355 | Stability | |||
| circMAP3K460 | Translation | |||
| circSORE61 | Stability | |||
| circARL366 | Circularization | |||
| circHPS569 | Cytoplasmic output | |||
| CRC | LncPTTG3P41 | Stability | ||
| LncRP1143 | Nuclear accumulation | |||
| circALG164 | Stability | |||
| circ166267 | N/A | |||
| LUAD | LncLCAT347 | Stability | ||
| pri- miR-143-3p71 | Maturation | |||
| pri-miR-106b133 | Maturation | |||
| NSCLC | LncRMRP41 | Stability | ||
| circIGF2BP367 | Circularization | |||
| PAC | LncLIFR-AS151 | Stability | ||
| LncANRIL58 | Splicing | |||
| pri-miR-2570 | Maturation | |||
| BRC | LNC0095846 | Stability | ||
| LncMALAT1122 | Stability | |||
| PC | LncNEAT1-158 | Scaffold | ||
| LncSNHG754 | Stability | |||
| GC | LncTHAP7-AS148 | Stability | ||
| EOC | LncRHPN1-AS144 | Stability | ||
| TET | LncMALAT151 | Stability | ||
| RCC | LncDUXAP945 | Stability | ||
| HNSCC | LncAROD76 | Stability | ||
| HPSCC | circCUX162 | Stability | ||
| ESCC | pri-miR-320b72 | Maturation | ||
| Tumor suppressor | LUAD | circASK165 | Stability | |
| GBM | LncMALAT153 | Stability | ||
| HCC | LncMEG356 | N/A | ||
| METTL14 | Oncogene | HNSCC | LncAROD76 | Stability |
| NPC | LncFAM225A74 | Stability | ||
| HCC | LncMIR155HG79 | Stability | ||
| GC | LNC0132075 | Stability | ||
| circORC583 | N/A | |||
| TLBL | pri-miR-21185 | Maturation | ||
| BRC | miR-146a-5p84 | Reshape the miRNA profile | ||
| CRC | LncXIST78 | Stability | ||
| PAC | LncPACERR82 | Scaffold | ||
| RCC | LncLSG181 | Scaffold | ||
| Tumor suppressor | RCC | LncNEAT180 | Stability | |
| Tumor suppressor | LUAD | LncHCG1177 | Stability | |
| METTL16 | Tumor suppressor | HCC | LncRAB11B-AS197 | Stability |
| METTL3/14 | Oncogene | HCC | LncAROD49 | Stability |
| Oncogene | NSCLC | circNDUFB286 | Scaffold | |
| WTAP | Oncogene | NPC | LncDIAPH1-AS188 | Stability |
| Oncogene | OS | LncFOXD2-AS150 | Stability | |
| Oncogene | BRC | LncDLGAP1-AS190 | Stability | |
| KIAA1429 | Oncogene | GC | LNC00958149 | Stability |
| Tumor suppressor | HCC | circDLC191 | N/A | |
| RBM15 | Oncogene | ESCC | LncMALAT194 | Scaffold |
CC cervical cancer, HCC hepatocellular carcinoma, CRC colorectal cancer, LUAD lung adenocarcinoma, NSCLC non-small cell lung cancer, PAC pancreatic cancer, BRC breast cancer, PC prostate cancer, GC gastric cancer, EOC epithelial ovarian cancer, TET thymic epithelial tumor, RCC renal cell carcinoma, HNSCC head and neck squamous cell carcinoma, HPSCC hypopharyngeal squamous cell carcinoma, ESCC esophageal squamous cell carcinoma, GBM glioblastoma multiforme, NPC nasopharyngeal carcinogenesis, TLBL T-cell lymphoblastic lymphoma.