. 2023 Mar 1;55(3):487–501. doi: 10.1038/s12276-023-00944-y

Table 2.

The role of demethylases and their regulated ncRNAs in various cancers.

Eraser	Role in cancer	Type	Target ncRNAs	Mechanism
FTO	Oncogene	ESCC	LNC00022⁹⁹	Stability
FTO	Oncogene	CC	LncHOXC13-AS¹⁰⁰	Stability
ALKBH5	Oncogene	OS	LncPVT1¹⁰⁴	Stability
		GBM	LncNEAT1¹⁰³	Stability
		LSCC	LncKCNQ1OT1¹¹⁷	Stability
		DLBCL	LncTRERNA1¹¹¹	Scaffold
		CRC	circ3823¹⁰²	Stability
		HCC	circCPSF6¹¹⁰	Stability
		NSCLC	miR-21–5p¹¹²	Silencing potency
		GC	LncNEAT1¹⁰⁷	N/A
		CRC	LncNEAT1¹⁰⁹	N/A
		LUAD	LncRMRP¹⁰⁸	N/A
	Tumor suppressor	ESCC	LNC00278¹⁰⁶	Translation
	Tumor suppressor	PAC	LncKCNK15-AS1¹⁰⁵	N/A

ESCC esophageal squamous cell carcinoma, CC cervical cancer, OS osteosarcoma, GBM glioblastoma multiforme, LSCC laryngeal squamous cell carcinoma, DLBCL diffuse large B-cell lymphoma, CRC colorectal cancer, HCC hepatocellular carcinoma, NSCLC non-small cell lung cancer, GC gastric cancer, LUAD lung adenocarcinoma, PAC pancreatic cancer.