Table 3.
Dysregulation of m6A-binding proteins in cancer.
| Reader | Role in cancer | Type | Target ncRNAs | Mechanism |
|---|---|---|---|---|
| YTHDF1 | Oncogene | CRC | circALG164 | Stability |
| Tumor suppressor | ESCC | LNC00278106 | Translation | |
| YTHDF2 | Oncogene | CRC | lncXIST78 | Stability |
| ESCC | LNC0002299 | Stability | ||
| LSCC | LncKCNQ1OT1117 | Stability | ||
| HCC | LNC127355 | Stability | ||
| circCPSF6110 | Stability | |||
| Tumor suppressor | EEC | LncFENDRR155 | Stability | |
| LUAD | circASK165 | Stability | ||
| YTHDF3 | Oncogene | BRC | LncMALAT1122 | Stability |
| Tumor suppressor | CRC | LncGAS5121 | Stability | |
| PAC | LncDICER1-AS1118 | Stability | ||
| YTHDC1 | Oncogene | ESCC | LncMALAT194 | Scaffold |
| HCC | circARL366 | Circularization | ||
| circHPS569 | Cytoplasmic output | |||
| RCC | LncLSG181 | Scaffold | ||
| circMET130 | Cytoplasmic output | |||
| NSCLC | circIGF2BP368 | Circularization | ||
| IGF2BP1 | Oncogene | HCC | LncAROD49 | Stability |
| circMDK134 | Stability | |||
| circMAP3K460 | Translation | |||
| IGF2BP2 | Oncogene | CRC | LncPTTG3P41 | Stability |
| circNSUN2141 | Cytoplasmic export | |||
| LncZFAS1139 | Stability | |||
| GBM | lncCASC9136 | Stability | ||
| NPC | LncDIAPH1-AS188 | Stability | ||
| RCC | LncDUXAP945 | Stability | ||
| PAC | LncDANCR137 | Stability | ||
| LncPACERR82 | Scaffold | |||
| TC | LncHAGLR138 | Stability | ||
| NSCLC | LncMALAT1140 | Stability | ||
| Tumor suppressor | NSCLC | circNDUFB286 | Scaffold | |
| LUAD | lncHCG1177 | Stability | ||
| IGF2BP3 | Oncogene | CC | lncKCNMB2-AS1143 | Stability |
| HNRNPA2B1 | Oncogene | LUAD | pri-miR-106b145 | Maturation |
| CRC | LncRP1143 | Nuclear accumulation | ||
| EIF3 | Oncogene | HCC | circARHGAP3519 | Translation |
| HuR | Oncogene | HCC | LncMIR155HG79 | Stability |
| GBM | LncMALAT153 | Stability | ||
| Tumor suppressor | HCC | circDLC191 | N/A |
CRC colorectal cancer, ESCC esophageal squamous cell carcinoma, LSCC laryngeal squamous cell carcinoma, HCC hepatocellular carcinoma, EEC endometrioid endometrial carcinoma, LUAD lung adenocarcinoma, BRC breast cancer, PAC pancreatic cancer, RCC renal cell carcinoma, NSCLC head and neck squamous cell carcinoma, GBM glioblastoma multiforme, NPC nasopharyngeal carcinogenesis, TC thyroid cancer, CC cervical cancer.