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. 2023 Mar 3;55(3):574–586. doi: 10.1038/s12276-023-00955-9

Fig. 2. Choroid plexus sequencing results confirmed that TLR2/NLRP3 pathway activation and tight junctions were abolished at 3 days after ICH-IVH.

Fig. 2

A GSEA enrichment plots demonstrating the degree of correlation between genes in the Toll receptor-, NOD-like receptor-, and tight-junction-associated categories and proteins in choroid plexus tissues from the control and ICH-IVH groups. B Immunofluorescent staining images of TLR2 and NLRP3 in the choroid plexus. Scale bar = 50 μm. C Representative gene abundance heatmap of transcriptome sequencing: TLR2, NLRP3, ZO-1. D Heatmap of proteins screened after proteomic sequencing GSEA enrichment analysis: TLR2, NLRP3, ZO-1. E Analysis of TLR2- and NLRP3-positive cell counting results of choroid plexus immunofluorescence staining (n = 3, one-way ANOVA). The results are expressed as the mean ± SD, **P < 0.01, ns P > 0.05.