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. 2023 Mar 3;55(3):574–586. doi: 10.1038/s12276-023-00955-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Heatmap of differentially expressed genes from transcriptome sequencing of Nlrp3^−/− rats versus WT rats. B Heatmap of differentially expressed proteins from proteome sequencing. C GSEA of sequencing results showing a diminished inflammatory response and altered lipid metabolism in Nlrp3^−/− rats. D Network images showing inflammatory, lipid-related, and potentially related genes after ICH-IVH with or without NLRP3 knockout. E Protein–protein interaction network of inflammatory and lipid-related proteins.