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. 2023 Mar 3;55(3):574–586. doi: 10.1038/s12276-023-00955-9

Fig. 8. Schematic representation of the mechanism.

Fig. 8

After ICH-IVH, NLRP3 was activated in the choroid plexus by TLR2. Next, NLRP3-mediated LD formation, and LDs combined with mitochondria to influence their function and mitochondrial ROS production. Mitochondrial ROS destroyed the B-CSFB through MMP9.