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. 2022 Aug 23;40(8):111263. doi: 10.1016/j.celrep.2022.111263

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Proposed model of PRC2 in transposon elimination

scnRNA-Ptiwi09 complexes target transposon transcripts and guide the PRC2 complex to transposon sequences. Ezl1 catalyzes H3K9me3 and H3K27me3, resulting in heterochromatinization and transcriptional repression. The domesticated transposase Pgm cleaves the transposon sequence, after which the double-stranded break is either repaired by NHEJ with the help of Ligase IV and Xrcc4, or telomeres are added de novo to the ends. Note that the interactions between the subunits depicted in the schematic do not represent precise interactions.