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. 2023 Apr 4;9:36. doi: 10.1038/s41421-023-00527-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Alignment of the monomeric dTRPA1-A structures of two states. Monomers from state-1 and state-2 are coloured grey and marine blue, respectively. b Structure alignments of the pore region between two states. c Structure alignments of the VSLD region between two states. d The nexus region exhibits a large rotation around the pivotal point (shown as a red circle) at the joint of preS1 and S1 helices. e Comparison of the pore region of dTRPA1-A in two states. Zoomed views of the upper selectivity filter and the lower gate are shown from two perpendicular angles. The constriction-site-forming residues are shown as sticks. f Pore depiction of dTRPA1-A in state-1 and state-2. A ribbon diagram is shown for the pore region from diagonally opposed subunits. Side chains of the constricting sites are shown as sticks. The upper gate is formed by residues L980, G981 and E982, and the lower gate is formed by I1024 and V1028. The ion conduction pore, calculated using HOLE2⁵⁷, is shown as magenta or orange mesh for state-1 or state-2, respectively. g Calculated pore radius along the channel. The lower gates have almost identical radii, approximately 1 Å, indicating a nonconductive state for both structures.