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. 2023 Apr 4;9:36. doi: 10.1038/s41421-023-00527-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Zoomed views of the structure alignment between monomeric dTRPA1-A in two states. Monomers from state-1 and state-2 are coloured grey and marine blue, respectively. The IFH observed in state-1 is shown in magenta. b Zoomed views of the IFH and the IFH-loop. c Interactions between the pre-S1, S1 and TRP helices. Side chains of the surrounding structure are coloured by atom type, with carbon shown in yellow. Hydrogen bonds are indicated by red dashed lines. d Heat-induced current densities for WT dTRPA1-A and the IFH mutants. Independent experiments were repeated for at least four times for each construct (n = 6 for all, except K750A where n = 4; and D1085A, G749A and E1054A where n = 5). **P = 0.002, ***P < 0.0005, and ****P < 0.0001 for WT versus mutants (one-way ANOVA with Dunnett’s multiple comparisons test). Data are mean ± s.e.m. e NMM-induced current densities at −60 mV for WT dTRPA1-A and the IFH mutants. Independent experiments were repeated six times for each construct (n = 6 for all). ns not significant, **P = 0.0016, and ****P < 0.0001 for WT versus mutants (one-way ANOVA with Dunnett’s multiple comparisons test). Data are mean ± s.e.m.