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. 2023 Apr 4;13:5511. doi: 10.1038/s41598-023-32710-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of selected MUFAs and PUFAs on IL-1β secretion by LPS-treated human THP-1 monocytes. (A) Quantitative results of levels of IL-1β in the conditioned media of THP-1 cells treated with selected FAs at different doses and 100 ng/mL of LPS for 24 h. Data are presented as mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 verses 0 µM vehicle group, Dunnett’s multiple comparisons after one-way ANOVAs. n = 9. (B) Fold changes in levels of IL-1β in the conditioned media between 50 µM and 0 µM (vehicle control) among the selected fatty acids with LPS for 24 h. The asterisks indicate significance in post-hoc comparison (50 µM vs. 0 µM) shown in panel (A).