Table 2.
Brain and metabolites features included in combined support-vector machine model of obesity.
| Column name | Info | SVM weight | P-value | T-value |
|---|---|---|---|---|
| 1-oleoyl-GPC (18:1) | Metabolite | − 3.20823e−05 | 0.3254347 | − 0.9875739 |
| Glycocholate | Metabolite | − 8.2497e−06 | 0.2450839 | − 1.1683452 |
| Pregnen-diol disulfate* | Metabolite | − 5.24364e−05 | 0.0766891 | − 1.7862797 |
| Nicotinate ribonucleoside | Metabolite | − 1.16909e−05 | 0.5345713 | − 0.6229187 |
| 2-hydroxypalmitate | Metabolite | − 8.8495e-06 | 0.0279664 | − 2.2259563 |
| 12-ketolithocholate | Metabolite | − 6.062e-07 | 0.6234562 | − 0.4922853 |
| 11beta-hydroxyandrosterone sulfate (2) | Metabolite | − 6.3292e-06 | 0.1132935 | − 1.5957305 |
| N-stearoyl-sphinganine (d18:0/18:0)* | Metabolite | 2.2885e−06 | 0.9127752 | 0.10978 |
| Pantoate | Metabolite | − 5.9953e−06 | 0.0844496 | − 1.7404801 |
| 5-hydroxyhexanoate | Metabolite | − 1.05904e−05 | 0.3068464 | − 1.026423 |
| Imidazole propionate | Metabolite | 2.7469e−06 | 0.9937212 | − 0.0078865 |
| Agmatine | Metabolite | − 2.20964e−05 | 0.1105004 | −1.6083507 |
| N-methylproline | Metabolite | − 1.37931e−05 | 0.3443564 | – 0.9495022 |
| Arabitol/xylitol | Metabolite | − 2.07102e−05 | 0.1675273 | − 1.3889653 |
| Deoxymugineic acid | Metabolite | − 9.3404e−06 | 0.2403965 | − 1.1800981 |
| Theobromine | Metabolite | − 4.6408e−06 | 0.8264974 | − 0.219696 |
| Stachydrine | Metabolite | 2.3491e−06 | 0.9693121 | 0.0385549 |
| Docosahexaenoylcarnitine (C22:6)* | Metabolite | − 7.433e−06 | 0.0613478 | − 1.8894642 |
| Carboxyibuprofen | Metabolite | − 2.25928e−05 | 0.4496436 | − 0.7586004 |
| Hyocholate | Metabolite | − 2.7928e−06 | 0.4151871 | − 0.817757 |
| 3,7-dimethylurate | Metabolite | − 4.1805e−06 | 0.7599397 | − 0.3062874 |
| 7-methylxanthine | Metabolite | − 2.2189e−06 | 0.5315353 | − 0.6275615 |
| (R)-salsolinol | Metabolite | − 2.21099e−05 | 0.2229156 | − 1.225434 |
| 5alpha-androstan-3alpha,17beta-diol disulfate | Metabolite | − 7.7926e−06 | 0.2266135 | − 1.2156354 |
| Curcumin | Metabolite | − 7.1795e−06 | 0.1972666 | − 1.2968855 |
| Docosadienoate (22:2n6) | Metabolite | − 6.8086e−06 | 0.2522873 | − 1.1505912 |
| Genistein | Metabolite | 4.88011e−05 | 0.6114582 | 0.5093853 |
| 2′-deoxyadenosine 5′-monophosphate | Metabolite | 1.2038e−06 | 0.785891 | − 0.2722852 |
| 2-(4-hydroxyphenyl)propionate | Metabolite | 1.64756e−05 | 0.2969804 | 1.0476857 |
| Piperine | Metabolite | 3.29415e−05 | 0.5037286 | 0.6707439 |
| 5-(2-Hydroxyethyl)-4-methylthiazole | Metabolite | − 9.7784e−06 | 0.9918073 | 0.0102906 |
| Tyrosol | Metabolite | 1.02517e−05 | 0.0755582 | 1.7932698 |
| N-butyryl-leucine | Metabolite | 5.3575e−06 | 0.0931012 | 1.6933227 |
| I-urobilinogen | Metabolite | 7.58174e−05 | 0.0195845 | 2.36738 |
| N-(2-furoyl)glycine | Metabolite | 2.14319e−05 | 0.3071521 | 1.0257716 |
| OAHSA (18:1/OH-18:0) | Metabolite | − 8.6601e−06 | 0.7071483 | 0.3766223 |
| AMP | Metabolite | − 2.3066e−06 | 0.2627772 | − 1.1253659 |
| Maltose | Metabolite | 2.7173e−06 | 0.3679204 | − 0.9039334 |
| Sulfate of piperine metabolite C16H19NO3 (2)* | Metabolite | 2.01842e−05 | 0.1394363 | 1.488196 |
| gamma-Glutamylalanine | Metabolite | 3.4847e−06 | 0.1697141 | 1.3817916 |
| Docosahexaenoate (DHA; 22:6n3) | Metabolite | 1.79368e−05 | 0.5487737 | 0.6013752 |
| 1-linolenoylglycerol (18:3) | Metabolite | − 2.6022e−06 | 0.5024215 | 0.6728043 |
| 1-oleoylglycerol (18:1) | Metabolite | 5.74495e−05 | 0.2049111 | 1.2749096 |
| Stigmastadienone | Metabolite | 4.6773e−06 | 0.4839874 | 0.7021772 |
| Linoleoyl-linoleoyl-glycerol (18:2/18:2) [1]* | Metabolite | 5.4485e−06 | 0.0342553 | 2.1425781 |
| Levulinate (4-oxovalerate) | Metabolite | 2.1728e−06 | 0.2314901 | 1.2028887 |
| Sucralose | Metabolite | 8.6687e−06 | 0.116412 | 1.5819302 |
| 1,2-dilinoleoyl-GPC (18:2/18:2) | Metabolite | 1.16417e−05 | 0.8407669 | 0.2013676 |
| N-acetylisoleucine | Metabolite | 5.4118e−06 | 0.02041 | 2.3512972 |
| Acesulfame | Metabolite | 2.93443e−05 | 0.222516 | 1.2264998 |
| AvPathLength__R_LoInG_CInS | Somatosensory | − 0.0009482483 | 0.170343 | − 1.3797417 |
| AvPathLength__L_MPosCgG_S | Emotional Regulation | − 0.0009154738 | 0.0139718 | − 2.4961668 |
| AvPathLength__L_PosDCgG | Default Mode Network | − 0.0007531148 | 0.1134375 | − 1.5950865 |
| AvPathLength__R_InfFGOrp | Emotional Regulation | − 0.0005549889 | 0.4141841 | − 0.8195216 |
| NodeBWCent__R_PosCS | Somatosensory | − 0.0006092343 | 0.0692979 | − 1.8336098 |
| AvPathLength__L_InfCirIns | Somatosensory | − 0.0006176458 | 0.0244062 | − 2.2807316 |
| NodeBWCent__R_PosCG | Somatosensory | − 0.0005719311 | 0.6046272 | − 0.5191882 |
| NodeBWCent__L_RG | Emotional Regulation | − 0.0006018847 | 0.6067252 | − 0.5161723 |
| AvPathLength__R_PrCun | Default Mode Network | − 0.0005846671 | 0.0411581 | − 2.0651356 |
| NodeBWCent__L_ACgG_S | Emotional Regulation | − 0.0005199462 | 0.8344359 | − 0.2094906 |
| NodeBWCent__R_TrFPoG_S | Default Mode Network | − 0.000550803 | 0.4761666 | − 0.7148237 |
| AvPathLength__L_OcPo | Occipital | − 0.0005372031 | 0.3719004 | − 0.8964214 |
| AvPathLength__R_PosTrCoS | Interlobe | − 0.0005350337 | 0.1452779 | − 1.4663656 |
| NodeBWCent__R_AngG | Default Mode Network | − 0.0004671307 | 0.4646458 | − 0.7336653 |
| AvPathLength__R_PerCaS | Emotional Regulation | − 0.0004534601 | 0.0093628 | − 2.6430109 |
| AvPathLength__R_AOcS | Occipital | − 0.0004988374 | 0.0586744 | − 1.9096126 |
| NodeBWCent__L_CS | Somatosensory | − 0.0004482049 | 0.6791227 | − 0.4147156 |
| AvPathLength__R_SbOrS | Emotional Regulation | − 0.0005218257 | 0.0774365 | − 1.7817068 |
| AvPathLength__R_PaHipG | Emotional Regulation | − 0.0005000987 | 0.7399951 | − 0.3326619 |
| NodeBWCent__L_MOcG | Occipital | − 0.0004343127 | 0.1116088 | − 1.6033124 |
| NodeBWCent__R_MPosCgG_S | Emotional Regulation | − 0.000483703 | 0.3756011 | − 0.8894819 |
| NodeBWCent__L_PaHipG | Emotional Regulation | − 0.0004352314 | 0.5103618 | − 0.6603312 |
| AvPathLength__L_InfFGTrip | Emotional Regulation | − 0.000433419 | 0.2284636 | − 1.2107763 |
| AvPathLength__L_MACgG_S | Emotional Regulation | − 0.0003845632 | 0.0829239 | − 1.7492025 |
| NodeBWCent__L_PosCG | Somatosensory | − 0.0004257865 | 0.1377684 | − 1.4945595 |
| NodeBWCent__R_Hip | Emotional Regulation | − 0.0004448703 | 0.7521676 | 0.3165386 |
| NodeBWCent__L_TrFPoG_S | Default Mode Network | − 0.0004187044 | 0.5716848 | − 0.5671986 |
| NodeBWCent__R_OcPo | Occipital | − 0.0003524324 | 0.9782904 | − 0.0272716 |
| AvPathLength__L_FMarG_S | Executive | − 0.0004036164 | 0.2131851 | − 1.251794 |
| AvPathLength__R_SupPrCs | Somatosensory | − 0.0002847931 | 0.3299016 | − 0.9784583 |
| NodeBWCent__R_Tha | Somatosensory | − 0.0003020804 | 0.4789275 | − 0.7103462 |
| NodeBWCent__R_MOcG | Occipital | − 0.0003067178 | 0.3078318 | − 1.0243248 |
| NodeBWCent__L_SupFG | Somatosensory | − 0.0002481055 | 0.5374476 | 0.6185325 |
| NodeBWCent__R_SupFS | Somatosensory | − 0.0002719212 | 0.6366603 | − 0.4736319 |
| NodeBWCent__L_CaN | Core Reward | − 0.0002289915 | 0.0463734 | − 2.0137213 |
| NodeBWCent__L_PaCL_S | Somatosensory | − 0.0001960458 | 0.5392911 | − 0.6157276 |
| AvPathLength__L_InfFGOrp | Emotional Regulation | − 0.0002701086 | 0.69713 | 0.3901735 |
| NodeBWCent__R_SbPS | Executive | − 0.0002149309 | 0.7591009 | − 0.3073921 |
| NodeBWCent__L_Hip | Emotional Regulation | 3.375e−06 | 0.4010689 | − 0.8428374 |
| NodeBWCent__R_InfTS | Temporal | 0.0001339698 | 0.5679843 | 0.5726727 |
| NodeBWCent__L_Pu | Somatosensory | 0.0001385234 | 0.5944141 | 0.5339394 |
| NodeBWCent__L_HG | Temporal | 0.0001799849 | 0.2125041 | 1.2536713 |
| NodeBWCent__R_IntPS_TrPS | Executive Control | 0.0002065054 | 0.912869 | − 0.1096615 |
| AvPathLength__R_TrFPoG_S | Default Mode Network | 0.0001700514 | 0.6230364 | − 0.4928811 |
| NodeBWCent__R_InfFGTrip | Emotional Regulation | 0.0001712679 | 0.4691462 | 0.7262744 |
| AvPathLength__R_ShoInG | Salience | 0.0002558495 | 0.1916472 | 1.313446 |
| NodeBWCent__L_InfCirIns | Somatosensory | 0.000298333 | 0.3661217 | 0.9073451 |
| NodeBWCent__L_InfFGTrip | Emotional Regulation | 0.0002452258 | 0.2790149 | 1.0876706 |
| NodeBWCent__R_SupFG | Somatosensory | 0.0003080609 | 0.2651615 | 1.1197311 |
| AvPathLength__R_InfFGOpp | Emotional Regulation | 0.0002563451 | 0.6090979 | 0.512767 |
| NodeBWCent__L_SupFS | Somatosensory | 0.0003189446 | 0.1007301 | 1.6546121 |
| AvPathLength__R_OcPo | Occipital | 0.0003393655 | 0.5872989 | − 0.5442853 |
| AvPathLength__R_Cun | Occipital | 0.00039095 | 0.9285999 | − 0.0898031 |
| AvPathLength__R_ACirIns | Salience | 0.0003916695 | 0.0878444 | 1.7215257 |
| AvPathLength__L_SupTS | Temporal | 0.0003220023 | 0.8840551 | 0.1461548 |
| AvPathLength__R_TrTs | Temporal | 0.0003712902 | 0.2822812 | 1.0802726 |
| AvPathLength__L_SupPrCs | Somatosensory | 0.0003569259 | 0.8959603 | 0.1310557 |
| AvPathLength__L_InfPrCS | Somatosensory | 0.000369516 | 0.6345674 | 0.4765773 |
| AvPathLength__R_PosVCgG | Default Mode Network | 0.0003904446 | 0.4358497 | 0.7819521 |
| AvPathLength__L_TrFPoG_S | Default Mode Network | 0.0003353048 | 0.8599587 | − 0.1768227 |
| AvPathLength__L_JS | Parietal | 0.0004036897 | 0.5434692 | 0.6093882 |
| NodeBWCent__L_MTG | Default Mode Network | 0.0004397223 | 0.4000983 | 0.8445812 |
| AvPathLength__L_InfTS | Temporal | 0.000505792 | 0.4668332 | 0.730068 |
| NodeBWCent__L_PRCG | Somatosensory | 0.0004845014 | 0.0058443 | 2.8088183 |
| NodeBWCent__L_FMarG_S | Executive | 0.0005082393 | 0.2996283 | 1.0419329 |
| NodeBWCent__R_SupCirInS | Salience | 0.0005409756 | 0.2098923 | 1.2609129 |
| AvPathLength__L_ACirIns | Salience | 0.0005799921 | 0.253704 | 1.1471418 |
| NodeBWCent__R_SupTGLp | Temporal | 0.0005360867 | 0.0692834 | 1.8337069 |
| NodeBWCent__R_CS | Somatosensory | 0.0005749146 | 0.732848 | 0.3421693 |
| NodeBWCent__L_SupTGLp | Temporal | 0.0005546731 | 0.6895121 | 0.4005262 |
| NodeBWCent__L_PrCun | Default Mode Network | 0.0005835341 | 0.8516433 | 0.1874434 |
| NodeBWCent__L_SupOcG | Occipital | 0.000645764 | 0.1567469 | 1.4254113 |
| AvPathLength__R_InfPrCS | Somatosensory | 0.0006194332 | 0.4971359 | 0.6811658 |
| NodeBWCent__L_Tpo | Temporal | 0.0006079824 | 0.2851643 | 1.0737911 |
| AvPathLength__L_InfOcG_S | Occipital | 0.0006837278 | 0.049996 | 1.9808431 |
| AvPathLength__L_PerCaS | Emotional Regulation | 0.0009624533 | 0.5916009 | 0.538023 |