Table 1.
Description of all candidate predictors evaluated for the AMPREDICT PROsthetics prediction model.
| Predictors* | Description (when applicable) |
|---|---|
| Amputation and prosthetic prescription | |
| Amputation level | At time of prosthetic prescription |
| Ipsilateral reamputation | Between incident amputation and prosthetic prescription |
| Time to prosthetic prescription | From incident amputation |
| Demographics † | |
| Age | Years |
| Body mass index (BMI) | Kg/m2 |
| Marital status | Married versus not |
| Urban versus rural/highly rural | Current living environment |
| Comorbidities † | |
| Diabetes | |
| Peripheral artery disease (PAD) | Atherosclerosis of native arteries or bypass graft of the lower extremities with claudication, rest pain, ulceration or gangrene |
| Asthma | |
| Chronic obstructive pulmonary disease (COPD) | |
| Coronary artery disease (CAD) | |
| Congestive heart failure (CHP) | |
| Kidney failure | |
| Stroke | |
| Chronic liver disease | Categorized as alcoholic, non-alcoholic, and “any” which combined the two |
| Peripheral neuropathy | |
| Myocardial infarction | In the past 6 months |
| Dialysis | Currently |
| Mental health and health behaviors ‡ | |
| Mild cognitive impairment | |
| Post-traumatic stress disorder (PTSD) | |
| Schizophrenia/psychosis | Combined into a single predictor |
| Bipolar disorder | |
| Anxiety | |
| Depression | Categorized as no depression, depressive without major disorder, and major depressive disorder (MDD) |
| Tobacco use disorder | |
| Cocaine/opioid use disorder | |
| Alcohol misuse | Most recent Alcohol Use Disorders Identification Test (AUDIT-C) score) prior to prosthetic prescription categorized as mild, moderate, and severe separately by male and female29 |
| Prior revascularization procedure § | |
| Any prior revascularization | Included ipsilateral, contralateral, open and endovascular without a time component |
| Ipsilateral open | Categorized as none, recent (≤3 months) or distant (>3 months) prior to prosthetic prescription |
| Ipsilateral endovascular | Same as above |
| Contralateral open | Same as above |
| Contralateral endovascular | Same as above |
*
A set of fractional polynomial terms was considered for all continuous predictors (time to prosthetic prescription, age, and BMI) to allow for nonlinear associations with (logit) risk.30
†
Race and sex information were collected, but were not included in the prediction model development because the number of eligible females was too small, and race may simply be a surrogate for other predictors.
‡
History of ever/never being diagnosed in the past except for myocardial infarction and dialysis
§
Based on clinical experience that these procedures may influence healing, prosthetic fitting, and ultimately prosthetic mobility