Table 2.
Distribution of candidate predictors by AMPSIMM category for enrolled participants (N= 357)
| Variable | AMPSIMM 0-2 (n=72) | AMPSIMM 3 (n=63) | AMPSIMM 4 (n=110) | AMPSIMM 5-6 (n=112) |
|---|---|---|---|---|
|
| ||||
| n (%) or Mean (SD) | ||||
| Amputation Level | ||||
| TT | 52 (72%) | 41 (65%) | 73 (66%) | 100 (89%) |
| TF | 20 (28%) | 22 (35%) | 37 (34%) | 12 (11%) |
| Time to Prosthetic Prescription (days)* | 120.9 (80.8) | 110.3 (63.5) | 91.5 (66.4) | 93.3 (61.3) |
| Age (years)* | 67.1 (7.7) | 66.7 (6.4) | 65.8 (8.6) | 61.9 (8.7) |
| Race/Ethnicity | ||||
| Black | 18 (25%) | 22 (35%) | 24 (22%) | 16 (14%) |
| Hispanic | 4 (6%) | 3 (5%) | 2 (2%) | 5 (4%) |
| White | 39 (54%) | 37 (59%) | 76 (69%) | 84 (75%) |
| Other | 5 (7%) | 0 (0%) | 1 (1%) | 2 (2%) |
| Missing | 6 (8%) | 1 (2%) | 7 (6%) | 5 (4%) |
| Sex | ||||
| Male | 70 (97%) | 59 (94%) | 110 (100%) | 110 (98%) |
| Female | 2 (3%) | 4 (6%) | 0 (0%) | 2 (2%) |
| Marital Status | ||||
| Married | 35 (49%) | 35 (56%) | 48 (44%) | 45 (40%) |
| Not Married | 37 (51%) | 28 (44%) | 62 (56%) | 67 (60%) |
| Urban-Rural Classification | ||||
| Rural | 26 (36%) | 24 (38%) | 42 (38%) | 44 (39%) |
| Urban | 46 (64%) | 39 (62%) | 68 (62%) | 68 (61%) |
| BMI (kg/m2)* | 29.5 (7.5) | 29.9 (5.4) | 29.7 (7.0) | 30.8 (5.6) |
| Peripheral Artery Disease | 54 (75%) | 49 (78%) | 69 (63%) | 58 (52%) |
| Coronary Atherosclerosis | 48 (67%) | 44 (70%) | 50 (45%) | 48 (43%) |
| Heart Failure | 36 (50%) | 31 (49%) | 33 (30%) | 31 (28%) |
| Recent myocardial Infarction† | 5 (7%) | 6 (10%) | 7 (6%) | 10 (9%) |
| Diabetes | 64 (89%) | 61 (97%) | 91 (83%) | 106 (95%) |
| Kidney Dialysis | 8 (11%) | 11 (17%) | 5 (5%) | 3 (3%) |
| Chronic Obstructive Pulmonary Disease | 34 (47%) | 32 (51%) | 40 (36%) | 27 (24%) |
| Stroke | 20 (28%) | 18 (29%) | 19 (17%) | 15 (13%) |
| Chronic Liver Disease, alcoholic | 3 (4%) | 2 (3%) | 3 (3%) | 4 (4%) |
| Chronic Liver Disease, non-alcoholic | 9 (12%) | 6 (10%) | 11 (10%) | 9 (8%) |
| Chronic Liver Disease, any | 10 (14%) | 7 (11%) | 11 (10%) | 10 (9%) |
| Peripheral Neuropathy | 52 (72%) | 43 (68%) | 69 (63%) | 73 (65%) |
| Prior Revascularization (any)‡ | 34 (47%) | 25 (40%) | 44 (40%) | 20 (18%) |
| Ipsilateral (open) | ||||
| None | 52 (72%) | 46 (73%) | 93 (85%) | 103 (92%) |
| Distant | 17 (24%) | 15 (24%) | 14 (13%) | 8 (7%) |
| Recent | 3 (4%) | 2 (3%) | 3 (3%) | 1 (1%) |
| Ipsilateral (endo) | ||||
| None | 53 (74%) | 48 (76%) | 75 (68%) | 95 (85%) |
| Distant | 16 (22%) | 11 (17%) | 28 (25%) | 11 (10%) |
| Recent | 3 (4%) | 4 (6%) | 7 (6%) | 6 (5%) |
| Contralateral (open) | ||||
| None | 62 (86%) | 56 (89%) | 104 (95%) | 112 (100%) |
| Distant | 9 (12%) | 6 (10%) | 6 (5%) | 0 (0%) |
| Recent | 1 (1%) | 1 (2%) | 0 (0%) | 0 (0%) |
| Contralateral (endo) | ||||
| None | 60 (83%) | 58 (92%) | 93 (85%) | 111 (99%) |
| Distant | 9 (12%) | 4 (6%) | 16 (15%) | 1 (1%) |
| Recent | 3 (4%) | 1 (2%) | 1 (1%) | 0 (0%) |
| Mild Cognitive Impairment | 2 (3%) | 4 (6%) | 4 (4%) | 5 (4%) |
| Post-Traumatic Stress Disorder | 23 (32%) | 14 (22%) | 19 (17%) | 31 (28%) |
| Schizophrenia/Psychosis | 6 (8%) | 2 (3%) | 2 (2%) | 3 (3%) |
| Bipolar disorder | 5 (7%) | 6 (10%) | 5 (5%) | 5 (4%) |
| Anxiety disorder | 24 (33%) | 23 (37%) | 26 (24%) | 30 (27%) |
| Depression | ||||
| No Depression | 38 (53%) | 25 (40%) | 68 (62%) | 53 (47%) |
| Depressive Disorder (non-major) | 7 (10%) | 13 (21%) | 18 (16%) | 21 (19%) |
| Major Depressive Disorder (MDD) | 27 (38%) | 25 (40%) | 24 (22%) | 38 (34%) |
| AUDIT-C Category§ | ||||
| Mild | 67 (93%) | 59 (94%) | 103 (94%) | 104 (93%) |
| Moderate | 5 (7%) | 2 (3%) | 6 (5%) | 7 (6%) |
| Severe | 0 (0%) | 2 (3%) | 1 (1%) | 1 (1%) |
| Tobacco Use (ever)‖ | 54 (75%) | 38 (60%) | 77 (70%) | 59 (53%) |
| Cocaine Use Disorder | 5 (7%) | 6 (10%) | 2 (2%) | 2 (2%) |
| Opioid Use Disorder | 6 (8%) | 7 (11%) | 3 (3%) | 7 (6%) |
| Subsequent Ipsilateral Amputation | 10 (14%) | 13 (21%) | 16 (15%) | 16 (14%) |
Unless otherwise specified, all diagnoses represent any diagnosis prior to prosthetic prescription
*
At time of incident amputation
†
in past 6 months prior to prosthetic prescription
‡
All revascularizations are based on time prior to prosthetic prescription (any – any prior ipsilateral or contra); distant = > 90 days, recent - ≤ 90 days)
§
most recent prior to prosthetic prescription (Mild - Female: < 3, Male: < 4; Moderate - Female: ≥ 3 & < 8, Male: ≥ 4 & < 8; Severe ≥ 8 for both Male and Female)
‖
22 missing values. Multiple imputation techniques were used to generate values in the model building.