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. 2023 Mar 13;49(5):86. doi: 10.3892/or.2023.8523

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Copyright: © Yoshida et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Schematic diagram. Comprehensive miRNA sequencing revealed that 53 and 11 miRNAs were significantly upregulated or downregulated, respectively, in uterine LMS compared with myoma. In LMS-derived cells, miR-10b-5p overexpression suppressed cell proliferation and colony formation, and increased the proportion of cells in G1 phase. These results demonstrated that miR-10b-5p had tumor-suppressive roles in LMS development. miR/miRNA, microRNA; LMS, leiomyosarcoma.