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. 2022 Aug 16;40(7):111230. doi: 10.1016/j.celrep.2022.111230

Figure 6.

Figure 6

Gene expression within immune infiltrates

(A) Heatmap showing top differentially expressed genes between IPF immune infiltrates and all other ROIs.

(B) Immunofluoresent staining (pan-cytokeratin, CD45, and nuclei) of IPF tissue with an immune infiltrate ROI highlighted. Scale bar, 100 μm.

(C and D) Gene expression in ROIs for CD48 (C) and MS4A1 (D).

(E–H) Gene set variation analysis (GSVA) scores for ROIs for GO CD4 receptor binding (E), GO regulation of adaptive immune response (F), GO acute inflammatory response (G), and Hallmark TNFA signaling via NFKB (H).

(I–J) Expression in ROIs for CXCR4 (I) and CXCL12 (J). Statistical comparisons are relative to control alveolar septae. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 by Wilcoxon test with Benjamini-Hochberg multiple test correction.