REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-NFKBIZ antibody	Atlas Antibodies	RRID:AB_1854442; Cat#HPA010547
COMP Polyclonal Antibody, Alexa Fluor 555 Conjugated	Stratech	Cat#BS-10286R-A555-BSS
PLOD2-Specific Polyclonal antibody	Proteintech	RRID:AB_10733347; Cat#21214-1-AP
Goat anti-Rabbit IgG (H + L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 647	Thermo Fisher Scientific	RRID:AB_2535813; Cat#A-21245
Goat Anti-Rabbit IgG Antibody (H + L), Biotinylated	Vector Laboratories	RRID:AB_2313606; Cat#BA-1000
Biological samples
Lung tissue as reported in experimental model and subject details	University Hospital Southampton	N/A
Chemicals, peptides, and recombinant proteins
DCCM-1 cell culture media	Biological Industries	Cat#K1-0502
Penicillin/streptomycin	Sigma-Aldrich	Cat#P4333
Fetal Bovine Serum	Thermo-Fisher Scientific	Cat#10500-064
L-glutamine	Sigma-Aldrich	Cat#59202C
Haematoxylin 7211	Fisher Scientific	Cat#10034813
Eosin Y	Fisher Scientific	Cat#12677756
Gill’s haematoxylin	Sigma-Aldrich	Cat#GHS132-1L
Proteinase K (20mg/mL)	Life Technologies	Cat#AM2546
Critical Commercial Assays
RNAscope Hiplex v2 assay reagents	ACD Bio	Cat#324445
RNAscope HiPlex Probe - Hs-COMP-T3 - Homo sapiens cartilage oligomeric matrix protein	ACD Bio	Cat#457081-T3
RNAscope HiPlex Probe - Hs-SOD2-T5 - Homo sapiens superoxide dismutase 2 (SOD2) transcript	ACD Bio	Cat#500281-T5
RNAscopeHiPlex Probe - Hs-NFKBIZ-T6 - Homo sapiens NFKB inhibitor zeta (NFKBIZ) transcript	ACD Bio	Cat#497851-T6
RNAscope HiPlex Probe - Hs-COL1A2-T8 - Homo sapiens collagen type I alpha 2 (COL1A2)	ACD Bio	Cat#432721-T8
RNAscope HiPlex Probe - 1Hs-CRABP2-T9Homo sapiens cellular retinoic acid binding protein 2	ACD Bio	Cat#900161-T9
RNAscope® HiPlex Probe - Hs-SFTPC-T11 - Homo sapiens surfactant protein C (SFTPC) transcript	ACD Bio	Cat#452561-T11
GeoMx Cancer Transcriptome Atlas	Nanostring	Cat#GMX-RNA-NGS-CTA-4
GeoMx Solid Tumor TME Morphology Kit, Human RNA Compatible	Nanostring	Cat#GMX-RNA-MORPH-HST-12
GeoMx RNA Slide Prep Kit for FFPE	Nanostring	Cat#GMX-PREP-RNA-FFPE-12
GeoMx Seq Code Pack: A & B	Nanostring	Cat#GMX-NGS-SEQ-AB
Human IL-6 Quantikine ELISA Kit Human IL-6 Quantikine ELISA Kit	RnD Systems	RRID:AB_2893335 Cat#D6050
Deposited Data
Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis	NCBI Gene Expression Omnibus	GSE135893
Molecular phenotyping of the idiopathic interstitial pneumonias	NCBI Gene Expression Omnibus	GSE32537
Spatial transcriptome profiling identifies CREB1 as a regulator of core transcriptional programs in idiopathic pulmonary fibrosis	NCBI Gene Expression Omnibus	GSE169500
Experimental Models: Cell Lines
ATIIER:KRASV12 cell line	Gift of Julian Downward, Francis Crick Institute, London (Cancer Discov. 2013; 3:548–63. Immunity. 2017; 47:1083–99. Cell Death and Differentiation, 2019; 26:943-057)	N/A
Oligonucleotides
ON-TARGETplus siRNA SMARTpool	Dharmacon	Cat#L-013497-00-0010
NFKBIZ gene expression assay	Thermo Fisher Scientifc	Cat#Hs00230071
IL6 gene expression assay	Thermo Fisher Scientifc	Cat#Hs00174131_m1
GADD45B gene expression assay	Thermo Fisher Scientifc	Cat#Hs00169587_m1
Software and Algorithms
R	The R software Foundation	R version 4.0.2
Prism	Graphpad	Version 9.0.1
Hiplex Image Registration Software	ACD Bio	N/A