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. 2023 Mar 22;14:1091697. doi: 10.3389/fneur.2023.1091697

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Copyright © 2023 Zhou, Lin, Xu, Wang, Chen, Wang and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two well-established glaucoma animal models were set to mimic acute attack of APACG and chronic damage of CPACG. (A) Acute ocular hypertension model: IOP acutely increased to 60 mmHg by perfusion with normal saline into the anterior chamber, and the ocular hypertension was sustained for 2 h. (B) Three-micrometer magnetic microbeads were injected into the anterior chamber angle to mimic chronic ocular hypertension. The microbeads showed autofluorescence (bottom). Scale bars: 20 μm. (C) IOP began to increase after 2 days and reached the peak 2 weeks after the injection, IOP was measured at pre-treatment, 2, 4, 6, 8, and 10 days, and then every 5 days for 1 month after the surgery. n = 20 mice, **P < 0.01, ***P < 0.001.