Table 3.
Laboratory markers of chronic pain and stress in preterm infants.
| Marker | Extremely preterm infants, n = 19 | Very preterm infants, n = 72 | Moderate preterm infants, n = 49 | Kruskal–Wallis test | Р |
|---|---|---|---|---|---|
| Dopamine in urine, pg/ml | 136.10 (111.80; 163.90) |
121.80 (91.43; 165.20) |
159.55 (112.50; 238.90) |
H = 3.44; p = 0.179 | p1–2 = 1.000 |
| p1–3 = 1.000 | |||||
| p2–3 = 0.216 | |||||
| β-endorphin in urine, pg/ml | 26.48 (14.23; 44.60) |
32.80 (21.99; 50.95) |
23.80 (18.94; 37.81) |
H = 2.06; p = 0.357 | p1–2 = 1.000 |
| p1–3 = 1.000 | |||||
| p2–3 = 0.594 | |||||
| Serotonin in urine, ng/ml | 22.71 (14.77; 26.73) |
24.03 (17.55; 32.08) |
18.75 (14.26; 36.31) |
H = 0.68; p = 0.712 | p1–2 = 1.000 |
| p1–3 = 1.000 | |||||
| p2–3 = 1.000 | |||||
| Cortisol in saliva, μg/dl | 0.734 (0.187; 2.010) |
0.325 (0.161; 0.801) |
0.246 (0.111; 0.585) |
H = 6.44; p = 0.040* | p1–2 = 0.142 |
| p1–3 = 0.033* | |||||
| p2–3 = 0.986 | |||||
| Cortisol in urine, ng/ml | 48.35 (37.34; 109.50) |
35.44 (18.97; 63.58) |
26.68 (16.19; 42.26) |
H = 7.26; p = 0.026* | p1–−2 = 0.094 |
| p1–3 = 0.021* | |||||
| p2–3 = 0.824 | |||||
| Oxytocin in urine, pg/ml | 39.09 (30.55; 52.52) |
39.96 (28.78; 62.50) |
34.14 (22.35; 61.19) |
H = 0.20; p = 0.904 | p1–2 = 1.000 |
| p1–3 = 1.000 | |||||
| p2–3 = 1.000 |
*Statistically significant results.