Table 2.

Advantages and limitations of amino acid and extensively hydrolyzed formulas.

	EHF	AAF
Similarities	High cost Unpleasant taste Elevated osmolarity Nutritionally adequate
Differences	May cause allergic response in 5%–10% of children with CMA	In 100% of children with CMA, they do not trigger an allergic mechanism related to CMP
	Presence of peptides with residual antigenic capacity (immunomodulatory effect)	Absence of bioactive peptides (does not produce immune modulation)

AAF, amino acid formula; CMA, cow’s milk allergy; CMP, cow’s milk proteins; EHF, extensively hydrolyzed formula.