Table 3.
Target hits on DrugBank Online of the top 1% genes.
| Top 1% nodes with matched targets on DrugBank | DrugBank top target | Top target E-value | Top target bit score | The number of drugs for all identified targets |
|---|---|---|---|---|
| AAW70716 | NADH dehydrogenase [ubiquinone] iron–sulfur protein 2, mitochondrial (Humans) | 0 | 561.222 | 2 |
| AAW71149 | Dihydrolipoyl dehydrogenase, mitochondrial (Humans) | 5.28E−134 | 394.815 | 11 |
| WBGene00222081 | Mitogen-activated protein kinase 10 (Humans) | 0 | 590.497 | 18 |
| WBGene00223114 | 40S ribosomal protein S2 (Humans) | 3.82E−134 | 379.407 | 1 |
| WBGene00224470 | Fumarate reductase flavoprotein subunit (Shewanella frigidimarina) | 4.27E−73 | 242.276 | 2 |
| WBGene00224578 | Rho-related GTP-binding protein RhoB (Humans) | 2.93E−21 | 85.8853 | 7 |
| WBGene00224796 | Fibroblast growth factor receptor 1 (Humans) | 1.36E−122 | 401.364 | 96 |
| WBGene00226447 | Phosphoribosylpyrophosphate synthetase (Plasmodium falciparum) | 1.82E−48 | 167.933 | 1 |
Full list of matched drug targets and related drugs is in Supplementary Table S6. Visualization of this data is in Figure 6 and Supplementary File S3.