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. 2023 Mar 22;14:1143796. doi: 10.3389/fimmu.2023.1143796

Figure 7.

Figure 7

Changes of coagulation, hematology, biochemistry and leukocyte subsets in rhesus monkeys during the early stage of SFTSV infection. Specifically, the proportion of mDC decreased on days 4-9 and pDC increased on day 1. The number of NK cell decreased on days 1-3 and the proportion of CD16+ CD56+ NK increased on days 4-9. The number of monocytes decreased and the proportion of CD14+CD16+ monocytes increased on day 1. No significant change in the number of CD4+ T and the proportion of CD4 Tem, CD4 Tcm, but both the proportions of HLA-DR+ CD4 Tem and HLA-DR+ CD4 Tcm increased on days 3-7 and days 1-4, respectively. The number of CD8+ T decreased on day 4, and the proportion of CD8 Tem decreased on day 4. However, the proportion of CD8 Tcm increased on days 4-7. In addition, both the proportions of HLA-DR+ CD8 Tem and HLA-DR+ CD8 Tcm increased on day 1 and day 4, respectively. The number of B cells and the proportion of activated memory B cells decreased on days 4-7 and days 3, 4 respectively. The proportion of CD80+ and CD86+ B cells increased on days 3-7 and days 3, 4, respectively.