Table 2.
Potential determinants of survival among 1045 patients with untreated HCC.
| Total, N=1045 | Survival <12 months, n = 810 (%) | Survival ≥12 months, n = 235 (%) | Mean survival months | P value | |
|---|---|---|---|---|---|
| Age, y <60 ≥60 |
457 588 |
368 (80.5) 442 (75.2) |
89 (19.5) 146 (24.8) |
12.77 12.38 |
0.047 |
| BCLC stage | < .0001 | ||||
| 0/A (very early, early) B (intermediate) C (advanced) D (end stage) |
123 96 599 227 |
35 (28.5) 50 (52.1) 505 (84.3) 220 (96.9) |
88 (71.5) 46 (47.9) 94 (15.7) 7 (3.1) |
41.33 22.08 8.87 2.64 |
|
| Etiology | 0.001 | ||||
| HBV HCV HBV+HCV Alcohol use Others |
544 102 24 155 220 |
446 (82.0) 70 (68.6) 18 (75.0) 106 (68.4) 170 (77.3) |
98 (18.0) 32 (31.4) 6 (25.0) 49 (31.6) 50 (22.7) |
11.57 12.74 10.42 16.5 12.37 |
|
| Child-Pugh class | < .0001 | ||||
| A B C |
469 428 148 |
291 (62.0) 376 (87.9) 143 (96.6) |
178 (38.0) 52 (12.1) 5 (3.4) |
20.53 7.26 2.6 |
|
| MELD score (n = 984, missing = 61) <10 ≥10 |
401 583 |
261 (65.1) 513 (88.0) |
140 (34.9) 70 (12.0) |
18.42 7.4 |
< .0001 |
| Serum AFP level (ng/ml) <1000 ≥1000 |
610 435 |
417 (68.4) 393 (90.3) |
193 (31.6) 42 (9.7) |
17.25 5.97 |
< .0001 |
| ECOG performance status | < .0001 | ||||
| 0 1 2 3 4 |
550 265 119 65 46 |
374 (68.0) 220 (83.0) 107 (89.9) 64 (98.5) 45 (97.8) |
176 (32.0) 45 (17.0) 12 (10.1) 1 (1.5) 1 (2.2) |
17.31 9.49 6.92 2.57 1.98 |
|
| Encephalopathy (n = 1042, missing = 3) |
0.015 | ||||
| None Mild (confusion) Severe (Stupor or coma) |
1006 27 9 |
773 (76.8) 26 (96.3) 9 (100.0) |
233 (23.2) 1 (3.7) 0 (0.0) |
12.85 4.41 1.44 |
|
| Ascites (n = 1037, missing = 8) |
< .0001 | ||||
| None Mild Moderate to severe |
523 297 217 |
339 (64.8) 257 (86.5) 208 (95.9) |
184 (35.2) 40 (13.5) 9 (4.1) |
19.64 7.04 3.28 |
|
| Tumor no. | < .0001 | ||||
| Single Multiple |
439 606 |
297 (67.7) 513 (84.7) |
142 (32.3) 93 (15.3) |
18.48 8.26 |
|
| Tumor size | < .0001 | ||||
| < 5cm ≥ 5cm |
279 766 |
148 (53.0) 662 (86.4) |
131 (47.0) 104 (13.6) |
15.84 6.07 |
|
| Portal vein invasion No Yes |
517 528 |
315 (61.0) 495 (94.0) |
202 (39.0) 33 (6.0) |
21.13 4.16 |
< .0001 |