TABLE 4.

Associations between the laxatives prescribed during the first trimester of pregnancy and MCM risk.

Variables	Sample size	No. of MCMs	Crude OR (95% CI)	Adjusted OR (95% CI)
Analysis adjusted for multiple confounding factors	10,302	708	0.895 (0.606–1.322)	0.889 (0.599–1.320)
Sensitivity Analysis 1: Only women who did not receive a suspected teratogenic drug prescription	10,264	707	0.895 (0.606–1.322)	0.891 (0.601–1.323)
Sensitivity Analysis 2: Only women who were prescribed laxatives for more than 30 days during the first trimester	1,495	107	1.158 (0.604–2.219)	0.968 (0.479–1.955)
Sensitivity Analysis 3: Excluded women who were prescribed both MgO and KRR	10,200	698	0.736 (0.455–1.19)	0.755 (0.466–1.225)
Sensitivity analysis 4: Excluded women who were only prescribed MgO or KRR as needed	10,185	698	0.911 (0.617–1.347)	0.905 (0.610–1.344)

Abbreviations: MgO = magnesium oxide; MCM, major congenital malformation; OR, odds ratio; CI, confidence interval; KRR, Kampo-containing rhubarb rhizome.