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. 2023 Mar 22;14:1140406. doi: 10.3389/fgene.2023.1140406

FIGURE 4.

FIGURE 4

Amino acid alignment and prediction of the protein conformational changes of p.F1108del and p.E502K of the FLT4 gene, and the diagram of the FLT4 protein. (A) Multiple sequence alignment of the FLT4 homeodomain from different species of vertebrates and X-tropicalis showing the evolutionary conservation of the glutamic residue at position 502 (highlighted in red box), and models of the wild-type and mutant E502K homeodomains of FLT4 were constructed with SWISS-MODEL. (B) Multiple sequence alignment of the FLT4 homeodomain from different species of vertebrates,X-tropicalis and Zebrafish showing the evolutionary conservation of the phenylalanine acid at position 1,108 (highlighted in red box), and models of the wild-type and mutant F1108del homeodomains of FLT4 were constructed with SWISS-MODEL. (C) Diagram of the FLT4 protein showing the functional domains (Ig1 to Ig7 domains and TKI, TKII), and the location of p. E502K and p.F1108del.