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. 2023 Mar 22;14:1122125. doi: 10.3389/fendo.2023.1122125

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Copyright © 2023 Matsuno, Yokoe, Nagatsuka, Morihara, Moriwaki and Asahi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced cardiac function in Ogt-Tg mice after TAC4W. (A) Hearts of representative WT and Ogt-Tg mice after TAC4W. Scale bars, 5mm. (B) Heart weight/body weight ratio (HW/BW, in mg/g) in TAC-treated WT and Ogt-Tg mice. The data were analyzed using two-way analysis of variance (ANOVA) followed by Tukey’s test. Values are shown as the mean ± SD value (n=3). *P<0.05. (C–F) Echocardiographic parameters of the mice; (C) EF, ejection fraction, (D) FS, fractional shortening, (E) LVIDd, end-diastolic left ventricular (LV) internal dimension, (F) LVIDs, end-systolic LV internal dimension. The data were evaluated by two-way analysis of variance (ANOVA), followed by Tukey’s test. **p<0.01. *p<0.05. n.s., not significant.