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. 2023 Mar 22;14:1122125. doi: 10.3389/fendo.2023.1122125

Figure 4.

Figure 4

Restoration of compensatory cardiac hypertrophy and fibrosis by the treatment of TDZD-8 in Ogt-Tg mice after TAC4W. (A–F) Masson's trichrome staining in heart tissues from TAC4W-treated WT and Ogt-Tg mice with or without TDZD-8 (10 mg/kg/day, 3 weeks, IP). Scale bar: (A, B) = 1000 μm, (C, D) = 50 μm. (E) Quantitative analysis of interventricular wall thickness evaluated by Masson's trichrome staining presented in (A–D). The data were evaluated by two-way analysis of variance (ANOVA) followed by Tukey’s test. Values are shown as mean±SD (n=3). *P<0.05. (F) Quantitative analysis of cardiac fibrosis evaluated by Masson's trichrome staining presented in (A–D). The data were evaluated by two-way analysis of variance (ANOVA) followed by Tukey’s test. Values are shown as mean±SD (n=3). *P<0.05. TAC, transverse aortic constriction.