Table 1.

Summary of studies about the role of T2R38 receptor in COVID-19

Author	Measured outcome	Result
Barham et al (16) 2020	Clinical course of SARS-CoV-2	All patients requiring hospitalization were reported as nontasters, whereas all other patients, not requiring admissionwere reported as tasters (p<0.001)
Risso et al (56) 2022	Assessing the frequency of PAV and AVI alleles in COVID-19 patients with severe or non-severe symptoms compared to healthy subjects	No significant relationship between TAS2R38 genotypes and presence or the severity of COVID-19 infection
Castaldo et al (34) 2020	Sinonasal disease severity and pulmonary P. a colonization in CF patients compared to controls	Frequency of the PAV allele was significantly lower in CF patients with nasal polyposis requiring surgery and, in CF patients with chronic pulmonary P. a colonization
Adappa et al (35) 2014	Correlation of TAS2R38 genotype with CRS	The frequency of PAV/PAV genotype is lower in patients failing medical therapy, necessitating FESS compared to controls (p=0.0383)