Table 2.
Clinicopathological characteristics and selected biomarkers across abnormal p53 expression patterns in HGSC
| Abnormal OE | % | Abnormal CA | % | Abnormal CY | % | Total | % | P value | ||
|---|---|---|---|---|---|---|---|---|---|---|
| HGSC | Total | 3,221 | 1,176 | 233 | 4,630 | |||||
| Age | Mean | 60.5 | 60 | 61.2 | 0.121 | |||||
| Range | 26–93 | 28–91 | 35–87 | |||||||
| Stage | I/II | 583 | 19.2 | 207 | 19.0 | 42 | 19.7 | 832 | 19.1 | 0.968 |
| III/IV | 2,461 | 80.8 | 884 | 81.0 | 171 | 80.3 | 3,516 | 80.9 | ||
| Unknown | 177 | 85 | 20 | 282 | ||||||
| Residual disease | Absent | 580 | 37.5 | 214 | 38.0 | 36 | 38.3 | 830 | 37.7 | 0.255 |
| Present | 965 | 62.5 | 349 | 62.0 | 58 | 61.7 | 1,372 | 62.3 | ||
| Unknown | 1,676 | 613 | 139 | 2,428 | ||||||
| CD8+ TILs | Negative | 386 | 15.7 | 148 | 16.5 | 26 | 14.3 | 560 | 15.8 | 0.818 |
| Low | 385 | 15.7 | 154 | 17.2 | 28 | 15.4 | 567 | 16.0 | ||
| Moderate | 1,068 | 43.5 | 385 | 43.0 | 84 | 46.2 | 1,537 | 43.5 | ||
| High | 618 | 25.2 | 208 | 23.2 | 44 | 24.2 | 870 | 24.6 | ||
| CDKN2A | Normal | 874 | 32.6 | 329 | 33.7 | 52 | 26.3 | 1,255 | 32.5 | 0.102 |
| Abnormal block | 1,637 | 61.0 | 601 | 61.6 | 135 | 68.2 | 2,373 | 61.5 | ||
| Abnormal absent | 171 | 6.4 | 46 | 4.7 | 11 | 5.6 | 228 | 5.9 | ||
| BRCA1/2 | Mutated | 197 | 24.9 | 70 | 24.1 | 11 | 22.0 | 278 | 24.6 | 0.880 |
| Wild type | 594 | 75.1 | 220 | 75.9 | 39 | 78.0 | 853 | 75.4 |
P values calculated excluding cases with ‘unknown’ information.