Table 3.

Clinicopathological characteristics and selected biomarkers across binary p53 expression status in EC and CCC

		p53 abnormal	%	p53 normal	%	Total	%	P value
EC	Total	116		857		973
Age	Mean	55		54.3		54.4		0.597
	Range	22–86		21–91		21–91
FIGO Stage	I/II	76	72.4	695	87.6	771	85.9	<0.001
	III/IV	29	27.6	98	12.4	127	14.1
Residual disease	Absent	51	44.0	371	43.3	422	43.4	0.697
	Unknown	57	49.1	442	51.6	499	51.3
	Present	8	6.9	44	5.1	52	5.3
CD8+ TILs	Negative	26	30.6	173	26.2	199	26.7	0.026
	Low	25	29.4	118	17.9	143	19.2
	Moderate	24	28.2	259	39.2	283	38.0
	High	10	11.8	110	16.7	120	16.1
CDKN2A	Normal	40	41.2	619	82.1	659	77.4	<0.001
	Abnormal block	40	41.2	36	4.8	76	8.9
	Abnormal absent	17	17.5	99	13.1	116	13.6
Grade	I/II	47	53.4	560	86.8	607	82.8	<0.001
	III	41	46.6	85	13.2	126	17.2
CCC	Total	86		662		748
Age	Mean	56.1		55.2				0.452
	Range	28–83		27–84
Stage	I/II	50	61.0	500	78.6	550	76.6	<0.001
	III/IV	32	39.0	136	21.4	168	23.4
Residual disease	Absent	32	37.2	292	44.1	324	43.3	<0.001
	Unknown	33	38.4	305	46.1	338	45.2
	Present	21	24.4	65	9.8	86	11.5
CD8+ TILs	Negative	20	29.4	266	50.3	286	47.9	<0.001
	Low	12	17.6	122	23.1	134	22.4
	Moderate	21	30.9	81	15.3	102	17.1
	High	15	22.1	60	11.3	75	12.6
CDKN2A	Normal	32	41.0	381	67.1	413	63.9	<0.001
	Abnormal block	34	43.6	70	12.3	104	16.1
	Abnormal absent	12	15.4	117	20.6	129	20.0