Table 2.
Univariate Associations of Phenotype z-Scores and Individual COPCs, Adjusted for Study Site and Demographics
| TMD |
Headache |
IBS |
LBP |
Fibromyalgia |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| QST measure | OR (95% CL) | P | OR (95% CL) | P | OR (95% CL) | P | OR (95% CL) | P | OR (95% CL) | P |
| PPT: Temporalis (r) | 3.94 (2.42, 6.41) | < .001 | 1.19 (0.94, 1.50) | .143 | 1.62 (1.14, 2.30) | .007 | 1.38 (0.99, 1.93) | .057 | 2.81 (1.31, 6.02) | .008 |
| PPT: Trapezius (r) | 1.85 (1.29, 2.66) | .001 | 1.08 (0.85, 1.37) | .534 | 1.41 (1.02, 1.96) | .039 | 1.21 (0.85, 1.71) | .286 | 4.94 (2.06, 11.80) | < .001 |
| PPT: Anterior tibialis (r) | 1.78 (1.28, 2.49) | .001 | 1.06 (0.83, 1.36) | .616 | 1.27 (0.94, 1.71) | .117 | 1.06 (0.77, 1.44) | .732 | 2.36 (1.36, 4.08) | .002 |
| MCPT (r) | 1.77 (1.25, 2.50) | .001 | 1.40 (1.12, 1.76) | .003 | 1.32 (0.99, 1.76) | .062 | 1.39 (1.00, 1.93) | .052 | 2.63 (1.18, 5.86) | .018 |
| MCP: Single stimulus (0–100) | 1.56 (1.24, 1.97) | < .001 | 1.18 (0.92, 1.50) | .196 | 1.16 (0.91, 1.47) | .233 | 1.27 (0.94, 1.72) | .124 | 1.48 (NE) | NE |
| MCP: Series of 10 stimuli (0-100) | 1.44 (1.09, 1.90) | .011 | 1.12 (0.89, 1.41) | .346 | 1.25 (0.98, 1.59) | .070 | 1.12 (0.84, 1.51) | .429 | 1.34 (NE) | NE |
| MCP: TS (−100 to 100) | 1.00 (0.73, 1.38) | .997 | 0.99 (0.78, 1.25) | .921 | 1.19 (0.94, 1.52) | .147 | 0.92 (0.68, 1.25) | .601 | 0.93 (NE) | NE |
| MCP: 15-s after-sensation (0 to 100) | 1.37 (1.07, 1.76) | .011 | 1.22 (0.96, 1.56) | .105 | 1.16 (0.93, 1.46) | .190 | 1.59 (1.20, 2.10) | .001 | 1.66 (NE) | NE |
| HPT, °C (r) | 1.24 (0.88, 1.74) | .222 | 1.22 (0.96, 1.55) | .101 | 1.36 (1.00, 1.85) | .052 | 1.03 (0.78, 1.34) | .848 | 1.49 (0.92, 2.42) | .104 |
| HP: Tolerance, °C (r) | 1.27 (0.92, 1.75) | .151 | 1.02 (0.77, 1.35) | .901 | 0.98 (0.70, 1.37) | .892 | 1.31 (0.99, 1.73) | .055 | 1.10 (0.81, 1.48) | .547 |
| HP: Single stimulus, (0 to 100) | 1.52 (1.06, 2.18) | .023 | 0.95 (0.72, 1.25) | .728 | 1.15 (0.81, 1.63) | .426 | 1.36 (0.93, 1.99) | .114 | 1.12 (0.80, 1.57) | .517 |
| HP: 10 stimuli AUC (0 to 100) | 1.68 (1.20, 2.36) | .003 | 1.08 (0.84, 1.40) | .544 | 1.19 (0.87, 1.63) | .287 | 1.34 (0.97, 1.86) | .078 | 1.34 (0.92, 1.97) | .131 |
| HP: Maximum of 10 stimuli (0 to 100) | 1.80 (1.28, 2.52) | .001 | 1.12 (0.87, 1.45) | .368 | 1.32 (0.96, 1.82) | .088 | 1.48 (1.06, 2.07) | .023 | 1.51 (0.96, 2.38) | .076 |
| HP: TS (0 to 100) | 1.17 (0.82, 1.67) | .374 | 1.03 (0.75, 1.42) | .835 | 1.08 (0.77, 1.52) | .660 | 1.00 (0.70, 1.42) | .980 | 1.41 (0.81, 2.44) | .225 |
| HP: 15-s aftersensation (0 to 100) | 1.20 (0.89, 1.61) | .233 | 1.09 (0.84, 1.41) | .515 | 1.19 (0.88, 1.60) | .266 | 1.33 (0.96, 1.84) | .090 | 1.61 (1.11, 2.34) | .012 |
Values in bold are significant (P < .05). AUC = area under the curve. OR = odds ratio; CL = confidence limit; (r) = reverse scoring (negative z scores used for standardized odds ratios represent increase in odds of being a case associated with reduction of 1 SD in the value of the variable); NE = not estimated due to failure of model convergence; PPT = pressure pain threshold; MCP(T) = mechanical cutaneous pain (threshold); HP(T) = heat pain (threshold); TS = temporal summation.