Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1976 Aug;35(4):377–380. doi: 10.1136/ard.35.4.377

Raised serum immunoglobulin E in Wegener's granulomatosis.

D L Conn, G J Gleich, R A DeRemee, T J McDonald
PMCID: PMC1007400  PMID: 970998

Abstract

Five patients with Wegner's granulomatosis were found to have significantly raised serum immunoglobulin E (IgE) levels. The rise in IgE was not related to the extent of clinical involvement, was not part of a generalized serum immunoglobulin rise, and was not associated with eosinophilia. Raised serum IgE may be a clue to the pathogenesis of this disease.

Full text

PDF
377

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fauci A. S., Wolff S. M., Johnson J. S. Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis. N Engl J Med. 1971 Dec 30;285(27):1493–1496. doi: 10.1056/NEJM197112302852701. [DOI] [PubMed] [Google Scholar]
  2. Fauci A. S., Wolff S. M. Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine (Baltimore) 1973 Nov;52(6):535–561. doi: 10.1097/00005792-197311000-00002. [DOI] [PubMed] [Google Scholar]
  3. Gleich G. J., Averbeck A. K., Swedlund H. A. Measurement of IgE in normal and allergic serum by radioimmunoassay. J Lab Clin Med. 1971 Apr;77(4):690–698. [PubMed] [Google Scholar]
  4. Goldman A. S., Lord R. A., Dupree E., Goldblum R. M., Smith C. W., Dahl E. V. Lack of suppression of certain immunoglobulin-producing lymphocytes in T-lymphocyte deficiency. Clin Immunol Immunopathol. 1974 Sep;3(1):69–78. doi: 10.1016/0090-1229(74)90024-5. [DOI] [PubMed] [Google Scholar]
  5. Henderson L. L., Swedlund H. A., Van Dellen R. G., Marcoux J. P., Carryer H. M., Peters G. A., Gleich G. J. Evaluation of IgE tests in an allergy practice. J Allergy Clin Immunol. 1971 Dec;48(6):361–365. doi: 10.1016/0091-6749(71)90082-0. [DOI] [PubMed] [Google Scholar]
  6. Johansson S. G., Bennich H. H., Berg T. The clinical significance of IgE. Prog Clin Immunol. 1972;1:157–181. [PubMed] [Google Scholar]
  7. Markowitz H., Tschida A. R. Automated quantitative immunochemical analysis of human immunoglobulins. Clin Chem. 1972 Nov;18(11):1364–1367. [PubMed] [Google Scholar]
  8. Patterson R., Fink J. N., Pruzansky J. J., Reed C., Roberts M., Slavin R., Zeiss C. R. Serum immunoglobulin levels in pulmonary allergic aspergillosis and certain other lung diseases, with special reference to immunoglobulin E. Am J Med. 1973 Jan;54(1):16–22. doi: 10.1016/0002-9343(73)90078-8. [DOI] [PubMed] [Google Scholar]
  9. Pierce C. W., Peavy D. L., Tadakuma T. Suppressor T cells as regulators of lymphocyte functions. Ann N Y Acad Sci. 1975 Jun 13;256:365–374. doi: 10.1111/j.1749-6632.1975.tb36063.x. [DOI] [PubMed] [Google Scholar]
  10. Stone S. P., Muller S. A., Gleich G. J. IgE levels in atopic dermatitis. Arch Dermatol. 1973 Dec;108(6):806–811. [PubMed] [Google Scholar]
  11. Tada T., Ishizaka K. Distribution of gamma E-forming cells in lymphoid tissues of the human and monkey. J Immunol. 1970 Feb;104(2):377–387. [PubMed] [Google Scholar]
  12. Winkelmann R. K., Gleich G. J. Chronic acral dermatitis: association with extreme elevations of IgE. JAMA. 1973 Jul 23;225(4):378–381. doi: 10.1001/jama.225.4.378. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES