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. 2023 Feb 1;24(4):e55362. doi: 10.15252/embr.202255362

Figure 2. Genomic binding of NuRD components.

Figure 2

  1. Principal component analysis of all NuRD component binding in neurons including replicates. Mi‐2/MEP‐1 (blue/purple) cluster independently of MTA1‐like (green) and HDAC1 (orange) reflecting greater similarity in their binding profiles.
  2. Heatmap and enrichment plots indicating binding at Mi‐2 peaks.
  3. Venn diagrams indicating the number of overlapping peaks between NuRD subunits. All intersections between peaks occur at statistically significant frequencies (Fisher's exact test P < 10−24).
  4. Peak annotation for Mi‐2, MEP‐1, MTA‐1like and HDAC1 peaks.
  5. Top enriched motifs at NuRD and dMec peaks.
  6. Heatmap indicating jaccard similarity statistic between chromatin states and NuRD peaks (Mi‐2, MEP‐1, MTA‐1like and HDAC1) and dMEC (Mi‐2 and MEP‐1 only), or HDAC1 peaks.