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. 2023 Feb 16;24(4):e55548. doi: 10.15252/embr.202255548

Figure 7. RET inhibition by CPT rescues disease phenotypes in mammalian AD models.

Figure 7

  • A, B
    Quantification of effect of CPT on ROS level as detected by staining with the H2O2 dye CM‐H2DCFDA (A), and on NAD+/NADH ratio (B) in control, FAD, and DS iPSC‐derived neurons.
  • C
    Quantification showing the effect of CPT on locomotor activity in PS19 tauopathy mice (n = 10 per group).
  • D
    Survival curves showing the effect of CPT on lifespan of PS19 tauopathy mice (*P < 0.05 logrank) (n = 9 in vehicle group, 8 in CPT group).

Data information: Data are shown as mean ± SEM (C). Survival curves were analyzed with logrank test along with Wang–Allison test for maximum lifespan. Asterisks indicate statistical significance (**P < 0.01, *P < 0.05) in single‐factor ANOVA with Scheffe's analysis as a post hoc test (A–C).