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. 2023 Feb 2;10(10):2206517. doi: 10.1002/advs.202206517

Figure 5.

Figure 5

EVs‐3SG ameliorate lung injury in the LPS‐induced ALI model. a) Schematic illustrating the experimental design used for model establishment and treatment. LPS and EVs were intratracheally administered. b) Results of the statistical analysis of IL‐6, TNF, and IL‐1β mRNA levels in lung tissue. c) Statistical analysis of the IL‐6, TNF, and IL‐1β levels in BALF detected using ELISA. d) H&E and immunohistochemical staining of lung tissues from mice administered different treatments showed that EVs‐3SG reduced the immune response and alleviated lung injury. Scale bar = 100 µm. e) Statistical analysis of the pathological lung injury score. f) Statistical analysis of F4/80+ macrophage area % per high power filed (HPF), n = 10 mice per group. Two sections per mouse were analyzed. g) Statistical analysis of MPO+ neutrophil area % per HPF, n = 10 mice per group, 2 slides per mouse were analyzed. ****p < 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05. The data are presented as the means ± SD.