Figure 7. PeSCs drive PD‐1 resistance in the tumor microenvironment.

• A
  Experimental setting.
• B–H
  (B) Tumor weight. FACS analysis of the percentage of CD45⁺ cells derived from the tumor (C), Ly6G⁺ MDSCs (D), F4/80⁺CD45⁺ cells (E), CD11c⁺CD45⁺ cells (F), CD4⁺CD45⁺ and IFNγ⁺CD4⁺ (G) and CD8⁺CD45⁺ and IFNγ⁺CD8⁺ (H). The results shown are cumulative from three independent experiments (each dot represents one mouse, 12–15 mice per group).
• I
  Experimental setting.
• J–O
  (J) Tumor weight. FACS analysis of CD44⁺PD‐1⁺Tim3⁺CD8⁺CD3⁺ T cells (K), CD107⁺CD8⁺ T cells (L), F4/80⁺CD163⁺ Macrophages (M), CD163⁺ Tim4⁺ Macrophages (N) and CD107⁺ Macrophages (O). The results shown are cumulative from three independent experiments (each dot represents one mouse, 9–12 mice per group).

Data information: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. The P‐values were calculated using Student's t‐test.

Source data are available online for this figure.