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Comparison of transdermal E2 and oral CE delivery. Modified [17]
| Transdermal E2 delivery | Oral CE delivery |
|---|---|
| Unmetabolized E2, at lower doses, directly to the blood stream | First pass liver metabolism |
| ↓ or ↔ TG | ↑ TG |
| ↓ LDL/HDL | ↓↓ LDL/HDL |
| ↔ Clotting factors | ↑ Clotting factors |
| ↔ Inflammatory factors | ↑ Inflammatory factors |
| ↑ E2 delivery to non-hepatic tissues | ↓ CE delivery to non-hepatic tissues |
