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. 2023 Apr 5;13:5563. doi: 10.1038/s41598-023-31537-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Volcano Plot for all probes included in PBC microarray analysis after background correction, normalization and merging of the replicated probes. The negative log10 of Limma’s test p-value for each probe are plotted against the difference (expressed as fold change, FC, log10 value) between children with low vs. high MVPA levels. Genes with p-value < 0.01 with positive FC (up-regulated in low MVPA children vs. high) are represented in orange and with negative FC (down-regulated in low MVPA children vs. high) are in blue. In addition, the 25 up- and down-regulated genes with p-value < 0.005 appear in darker color. The names of the top-10 up- and down-regulated genes with known function are also indicated.