Table 3.
Top 10 down- and up-regulated most significant (p < 0.005) genes by physical activity level in PBC ranked by Fold Change (FC, log2) indicating up-regulation (+) and down-regulation (−) by low physical activity, the Limma's p-value and FDR adjusted p-value.
| Gene symbol | Gene name | Sequence ID | Biological process | FC | p-value | p (adj.) |
|---|---|---|---|---|---|---|
| B4GALNT2 | Beta-1,4-N-acetyl-galactosaminyltransferase 2 | NM_153446 | Blood homeostasis | − 1.54 | 2.77E−03 | 0.999968 |
| ZNF229 | Zinc finger protein 229 | NM_014518 | Transcription/translation | − 1.52 | 1.02E−03 | 0.999968 |
| KLB | Klotho beta | NM_175737 | Cell signaling | − 1.42 | 4.94E−04 | 0.999968 |
| NMBR | Neuromedin B receptor | NM_002511 | Cell signaling | − 1.40 | 1.05E−03 | 0.999968 |
| NOX4 | NADPH oxidase 4 | NM_016931 | Redox Metabolism | − 1.31 | 8.25E−04 | 0.999968 |
| CFAP46 | Cilia and flagella associated protein 46 | NM_173572 | Cytoskeleton/structural function | − 1.22 | 4.75E−03 | 0.999968 |
| ODF1 | Outer dense fiber of sperm tails 1 | NM_024410 | Gamete generation | − 1.18 | 2.50E−03 | 0.999968 |
| SYPL2 | Synaptophysin like 2 | NM_001040709 | Transport | − 1.10 | 4.63E−03 | 0.999968 |
| TGFBR1 | Transforming growth factor beta receptor 1 | NM_004612 | Cell signaling | − 0.95 | 4.17E−04 | 0.999968 |
| TRIM9 | Tripartite motif containing 9 | NM_015163 | Protein metabolism | − 0.92 | 4.51E−03 | 0.999968 |
| BSND | Barttin CLCNK type accessory beta subunit | NM_057176 | Transport | + 1.27 | 3.82E−03 | 0.999968 |
| MGP | Matrix Gla protein | NM_001190839 | Cytoskeleton/structural function | + 1.30 | 1.54E−03 | 0.999968 |
| IRX5 | Iroquois homeobox 5 | NM_005853 | Development | + 1.40 | 4.89E−03 | 0.999968 |
| FBP2 | Fructose-bisphosphatase 2 | NM_003837 | Carbohydrate metabolism | + 1.41 | 2.19E−03 | 0.999968 |
| UBD | Ubiquitin D | NM_006398 | Protein metabolism | + 1.41 | 4.34E−03 | 0.999968 |
| SPATA31A1 | SPATA31 subfamily A member 1 | NM_001040065 | Gamete generation | + 1.46 | 3.01E−03 | 0.999968 |
| OR2B3 | Olfactory receptor family 2 subfamily B member 3 | NM_001005226 | Sensory perception (smell) | + 1.51 | 6.69E−04 | 0.999968 |
| OR4C13 | Olfactory receptor family 4 subfamily C member 13 | NM_001001955 | Sensory perception (smell) | + 1.57 | 1.98E−03 | 0.999968 |
| HOXD10 | Homeobox D10 | NM_002148 | Development | + 1.62 | 1.36E−03 | 0.999968 |
| S100B | S100 calcium binding protein B | NM_006272 | Development | + 1.66 | 4.57E−03 | 0.999968 |
Genes are ranked by FC.