Figure 1.
Parametric space showing the sorting mechanism for LBCS classification, where log K is the membrane/water partition coefficient and log Perm is the permeation rate through the liposome membrane at the designated temperature. Gray bin: APIs too permeable for liposome formulation; blue bin: neutral APIs too permeable but possible to move to the green bin if ionizable in liposome cavity by pH; green bin: APIs suitable for liposome formulation and even for thermally induced release; red bin: APIs suitable for liposome formulation but not for thermally induced release; yellow bin: lipophilic APIs suitable for entrapment in the liposome membrane. Positions of the four APIs investigated in this work are marked by the squares.