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. 2023 Mar 27;27:15–57. doi: 10.1016/j.bioactmat.2023.03.006

Fig. 12.

Fig. 12

(A) Particle-based nanostructured implant coatings: (a) Synthesis of siRNA-CTSK-loaded AuNPs by layer-by-layer assembly of chitosan and gelatin (cg) multilayers. (b) TEM images of monodispersed AuNPs, siRNA-loaded AuNPs, and (AuNP@siRNACTSK)cg. (c) Preparation of [(AuNP@siRNA-CTSK)cg]CG coatings by the assembly of (AuNP@siRNA-CTSK)cg on the implant surface. (d) SEM images of the Ti implant surface functionalized with [(AuNP@siRNA-CTSK)cg]CG [261].

(B) The application of Ti surface functionalized with [(AuNP@siRNA-CTSK)cg]CG as dental implants in a comprehensive beagle dog model. (a) The implantation of various Ti materials into the tooth extraction sockets. (b) Micro-CT images of dog maxillary bone after three months. (c) Micro-CT analysis of new bone formation around the implants after 12 weeks. (d) The quantitative data from the micro-CT analysis, including BV/TV, Tb.Th., Tb.N. (trabecular number), and Tb.Sp. (trabecular separation) [261]. Reprinted with permission from Ref. [261].