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Synthesis of PROTAC molecules. i) BrCH2COOtBu, K2CO3, DMF, r.t., overnight; ii) TFA, DCM, r.t., 5h.; iii) AlCl3, THF, 0°C to r.t., 1h; iv) 1,1′-(Azodicarbonyl)dipiperidine, tributylphosphine, Toluene, 0°C to r.t., overnight; v) HATU, DIPEA, DCM, r.t., overnight.; vi) H2, Pd/C, MeOH, overnight; vii) HATU, TEA, Ceritinib, DCM, r.t., overnight.
